Run Zadig as administrator by right clicking it and choosing run as administrator. Problem is that when I look into the device manager and plug in the second device again, also the second one (for which I did NOT change the driver) is listed as a libusbk device. Getting the RTL-SDR to work in Windows 10. Therefore, I have first installed the FTDI Serial Drivers, then unplugged one device and used the ZADIG tool to change the driver of the remaining adapter to libuskK.

Starting with v1.2.2.0, a GUI (filter wizard) is provided and it is only to attach the filter driver to particular USB device of interests. This feature allows libusb-win32 to communicate with many installed USB device. What I want to do is use one of the adapters with the 'standard' FTDI VCP Driver and the second adapter via libusk and python (libftdi). Features: Can be used as a filter driver for existing, already installed devices. Website Zadig is a Windows application that installs generic USB drivers, such as WinUSB, libusb-win32/libusb0.sys or libusbK, to help you access USB devices. One of the adapters has an FT245R inside, the other one an FT232R (I see that by reading the device information with the FT_Prog tool from FTDI). I use two kinds of USB/Serial Adapters on the same PC (Windows 8 / Windows 10). When using the latest Zadig (2.7 build 765) in Windows 11, the driver certificate fails, when trying to replace the existing driver (STTub30 (v3.0.4. I have found related questions on this topic, but not an answer to this specific question (at least none that is a solution).

Zadig windows 10 usb hid drivers